February 28, 2021

Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function

Yamazaki et al. generated conditional mouse models expressing apoE isoforms uniquely in vascular mural cells on a murine Apoe knockout background. They show that vascular-mural-cell-derived apoE4 impairs vascular function and behavior. Single-cell RNA sequencing reveals apoE4-associated astrogliosis along the vasculature and apoE3-related angiogenesis.


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