November 24, 2020

The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development

Nature Neuroscience, Published online: 13 July 2020; doi:10.1038/s41593-020-0672-0

The complement–microglia pathway is a key mediator of synapse elimination in development and disease. Cong et al. show that neurons endogenously express a complement inhibitor, SRPX2, that regulates synapse elimination in development.

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