January 19, 2021

The Anterior Cingulate Cortex Predicts Future States to Mediate Model-Based Action Selection

Akam et al. investigate mouse anterior cingulate cortex (ACC) in a sequential decision-making task, finding that ACC predicts future states given chosen actions and indicates when these predictions are violated. Transiently inhibiting ACC prevents mice from using observed state transitions to guide subsequent choices, impairing model-based reinforcement learning.

 Neuron

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