March 2, 2021

Human and Mouse Microglia Look Alike, but Age Differently

Researchers often turn to mice when they need an animal model for what microglia do in Alzheimer’s and other neurodegenerative diseases. Alas, along with the mice come nagging doubts about …

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Aged blood activates microglia

Research Highlights • Brain Endothelial Cells in the aged hippocampus of mice express an inflammatory transcriptional profile with focal upregulation of Vascular Cell Adhesion Molecule 1 (VCAM1).  • The shed, …

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