April 12, 2021

Standing By: How Intact Neurons React to Axon Injury

Nerve injury affects the neurophysiology of severed and bystander axons. In this issue of Neuron, Hsu et al. demonstrate that this early effect is cell-autonomous and driven by dSarm, independently of its NADase activity otherwise required for axon degeneration. The work shows that an axon injury signal spreads to intact neurons via glial cells.


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