November 24, 2020

Soma-Targeted Imaging of Neural Circuits by Ribosome Tethering

Chen et al. show that ribosome tethering can restrict fluorescent proteins to the soma, thereby eliminating neuropil fluorescence. This enables ultrasensitive detection of GFP in brain slices and eliminates the cross-contamination of somatic GCaMP signals during calcium imaging in mice and worms.

 Neuron

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