October 20, 2020

Selective Routing of Spatial Information Flow from Input to Output in Hippocampal Granule Cells

Zhang et al. simultaneously measure subthreshold EPSP and suprathreshold AP activity in morphologically identified dentate gyrus GCs in mice during spatial navigation, using intracellular patch-clamp recording. Although only a minor fraction of GCs shows spatially tuned spiking, a major fraction receives spatially tuned synaptic input. Intrinsic excitability controls input-output conversion.


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