January 25, 2021

Revisiting the Neural Architecture of Decision-Making: Univariate and Multivariate Evidence for System-Based Models in Adolescence

System-based theories are a popular approach to explaining the psychology of human decision making. Such theories posit that decision-making is governed by interactions between different psychological processes that arbitrate amongst each other for control over behavior. To date, system-based theories have received inconsistent support at the neural level, leading some to question their veracity. Here we examine the possibility that prior attempts to evaluate system-based theories have been limited by their reliance on predicting brain activity from behavior, and seek to advance evaluations of system-based models through modeling approaches that predict behavior from brain activity. Using within-subject decision-level modeling of fMRI data from a risk-taking task in a sample of over 2000 decisions across 51 adolescents-a population in which decision-making processes are particularly dynamic and consequential-we find support for system-based theories of decision-making. In particular, neural activity in lateral prefrontal cortex and a multivariate pattern of cognitive control both predicted a reduced likelihood of making a risky decision, whereas increased activity in the ventral striatum-a region typically associated with valuation processes-predicted a greater likelihood of engaging in risk-taking. These results comprise the first formalized within-subjects neuroimaging test of system-based theories, garnering support for the notion that competing systems drive decision behaviors.

 bioRxiv Subject Collection: Neuroscience

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