November 30, 2020

Reversal of prolonged obesity-associated cerebrovascular dysfunction by inhibiting microglial Tak1

Nature Neuroscience, Published online: 25 May 2020; doi:10.1038/s41593-020-0642-6

Shen et al. report that prolonged obesity is associated with cerebrovascular dysfunction and Tak1 activation in brainstem microglia. Pharmacological inhibition or genetic depletion of Tak1 restores cerebrovascular function in obese mice.

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