January 19, 2021

Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome

Pinto, Morelli et al. identify a critical role for activated microglia in cognitive impairments of Down syndrome mouse models that can be ameliorated by either depleting microglia or using anti-inflammatory drugs to reduce microglia activation. In this work, microglia activation is also revealed in brains of people with Down syndrome.


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