October 22, 2020

Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development

Brignani et al. devise intersectional genetic tools to dissect the mechanisms of substantia nigra (SN) development. Their data implicate Netrin-1 in the neuronal subtype-specific migration of midbrain dopamine neurons and show that Netrin-1 acts as a remotely produced and axon-derived guidance cue for the migration of SN GABAergic neurons.


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