November 30, 2020

Presynaptic Homeostasis Opposes Disease Progression in Mouse Models of ALS-Like Degeneration: Evidence for Homeostatic Neuroprotection

Synapse loss is an insidious aspect of aging and neurodegenerative disease, typically preceding symptoms of cognitive or motor decline. Orr et al. define a conserved mechanism of homeostatic plasticity (Drosophila and mice) that sustains neural function during an early phase of neuromuscular degenerative disease, underscoring a model of “homeostatic neuroprotection.”


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