May 18, 2021

Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation

Nature Neuroscience, Published online: 25 January 2021; doi:10.1038/s41593-020-00780-7

Synapse loss is prominent in the cortex in multiple sclerosis (MS). In a cortical MS model, Jafari et al. show that phagocytes remove synapses by engulfment, which is triggered by local calcium accumulations and prevented by blocking colony-stimulating factor 1 signaling.

 
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