February 25, 2021

Hormone helps prevent muscle loss in mice on high fat diets

A new study suggests that a hormone known to prevent weight gain and normalize metabolism can also help maintain healthy muscles in mice. The findings present new possibilities for treating …

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Sleep is vital to associating emotion with memory, study finds

When you slip into sleep, it’s easy to imagine that your brain shuts down, but new research suggests that groups of neurons activated during prior learning keep humming, tattooing memories …

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Basic cell health systems wear down in Huntington’s disease, analysis shows

Using an innovative computational approach to analyze vast brain cell gene expression datasets, researchers at MIT and Sorbonne Université have found that Huntington’s disease may progress to advanced stages more …

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INSULIN-LIKE GROWTH FACTOR I SENSITIZATION REJUVENATES SLEEP PATTERNS IN OLD MICE

Sleep disturbances are common during aging. Compared to young animals, old mice show altered sleep structure, with changes in both slow and fast lectrocorticographic (ECoG) activity and fewer transitions between …

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Scopolamine blocks context-dependent reinstatement of fear responses in rats

Return of fear poses a problem for extinction-based therapies of clinical anxiety. Experimental research has discovered several pathways to return of fear, one of which is known as reinstatement. Here, …

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Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice

Publication date: May 2021 Source: Neurobiology of Aging, Volume 101 Author(s): Sahar Roshanbin, Agata Aniszewska, Astrid Gumucio, Eliezer Masliah, Anna Erlandsson, Joakim Bergström, Martin Ingelsson, Sara Ekmark-Lewén  ScienceDirect Publication: Neurobiology …

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Automated classification of signal sources in mesoscale calcium imaging

Functional imaging of neural cell populations is critical for mapping intra- and inter-regional network dynamics across the neocortex. Recently we showed that an unsupervised machine learning decomposition of densely sampled …

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Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pRab10

Variants in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with increased risk for familial and sporadic Parkinson’s disease (PD). Pathogenic variants in LRRK2, including the common variant G2019S, …

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The Mesodiencephalic Junction as a Central Hub for Cerebro-Cerebellar Communication

Most studies investigating the impact of cerebral cortex (CC) onto the cerebellum highlight the role of the pontine mossy fibre system. However, cerebro-cerebellar communication may also be mediated by the …

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