November 28, 2020

Older, non-demented apolipoprotein ε4 carrier males show hyperactivation and structural differences in odor memory regions: a blood-oxygen-level-dependent and structural magnetic resonance imaging study

Publication date: September 2020

Source: Neurobiology of Aging, Volume 93


e4+males demonstrate hyperactivation of memory regions during odor recognition memory.
e4+males showed significant association between DRS scores and parahippocampal activation during false positives.
e4+males show greater recruitment of memory regions than e4+ females during hits.
Hyperactivation may suggest compensatory cognitive effort.

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