February 25, 2021

NMDA Receptors Singled out for Delayed Activation

In this issue of Neuron, Amin et al. (2021) recorded single NMDA receptors in synaptic-like conditions to reveal how unreliable coupling between agonist binding and channel opening depends on structured linkers. After neurotransmitter binding, a complicated molecular “discussion” ensues, dividing fast synaptic events from delayed openings and failures.


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