by Nature Neuroscience, Published online: 19 October 2020; doi:10.1038/s41593-020-00718-z
Peripheral macrophages located along motor axons react differently to neurodegeneration compared to CNS microglia in ALS mice. Modifying peripheral macrophages suppresses proinflammatory microglial responses, shifting them toward neuronal support.
Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival
