March 3, 2021

Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival

Nature Neuroscience, Published online: 19 October 2020; doi:10.1038/s41593-020-00718-z

Peripheral macrophages located along motor axons react differently to neurodegeneration compared to CNS microglia in ALS mice. Modifying peripheral macrophages suppresses proinflammatory microglial responses, shifting them toward neuronal support.

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