November 30, 2020

Microglia phagocytose myelin sheaths to modify developmental myelination

Nature Neuroscience, Published online: 06 July 2020; doi:10.1038/s41593-020-0654-2

Microglia refine the developing CNS by engulfing excess neurons and synapses. Hughes and Appel here show that microglia also prune myelin sheaths in a neuronal activity-regulated manner to sculpt developmental myelination.

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