November 25, 2020

Intracranial recordings reveal universal in-phase and in-antiphase functional connectivity between homologous brain regions in humans

Whether neuronal populations exhibit zero-lag (in-phase or in-antiphase) functional connectivity is a fundamental question when conceptualizing communication between cell assemblies. It also has profound implications on how we assess such interactions.

Given that the brain is a delayed network due to the finite conduction velocity of the electrical impulses traveling across its fibers, the existence of zero-lag functional connectivity may be considered improbable. However, in this study, using intracranial recordings we demonstrate that most inter-hemispheric connectivity between homologous cerebral regions is zero-lagged and that this type of connectivity is ubiquitous.

  1. Volume conduction can be safely discarded as a confounding factor since it is known to drop almost completely within short inter-electrode distances (< 20 mm) in intracranial recordings. This finding should guide future electrophysiological connectivity studies and highlight the importance of considering the role of zero-lag connectivity in our understanding of communication between cell assemblies.

 bioRxiv Subject Collection: Neuroscience

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