January 18, 2021

Interneuron diversity is required for compartment-specific feedback inhibition

Cortical inhibitory interneurons consist of many subtypes that have been associated with different functions. Here we use an optimization approach to show that two classes of interneurons are necessary to implement compartment-specific feedback inhibition to pyramidal cells. The two classes resemble PV-expressing and SST-expressing interneurons in their connectivity and short-term plasticity, suggesting a functional role for their diverse characteristics.

 bioRxiv Subject Collection: Neuroscience

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