April 12, 2021

Insights into the Irritating Mechanisms of TRPA1 Revealed by Cryo-EM

TRPA1 is a promising target for the development of novel treatments for chronic pain. In this issue of Neuron, Liu et al. (2021) report a novel non-covalent TRPA1-biased agonist, GNE551, revealing a unique binding pocket by cryo-EM and activation properties that pave a path toward new avenues in the treatment of chronic pain.

 Neuron

 Read More

Leave a Reply

%d bloggers like this: