April 12, 2021

Injury-Induced Inhibition of Bystander Neurons Requires dSarm and Signaling from Glia

Hsu et al. demonstrate that uninjured bystander neurons temporarily suppress their physiology in response to adjacent severed axons via cell-autonomous Cac/dSarm/MAPK signaling, independent of dSarm NADase activity. Injury signals are spread to bystander neurons via Draper-mediated signaling in glia. They propose a two-phase model for dSarm signaling in injured nerves.


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