April 12, 2021

Inflammation drives fibrotic scars in the CNS

Nature Neuroscience, Published online: 01 February 2021; doi:10.1038/s41593-020-00777-2

Fibrotic scarring after inflammation is well-characterized in peripheral tissues, but its role in the CNS is less clear. A new study shows that local proliferation of CNS fibroblasts drives fibrotic scar formation in response to circulating inflammatory cell infiltration in a model of multiple sclerosis, which may limit repair.

 
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