by Nature Neuroscience, Published online: 01 February 2021; doi:10.1038/s41593-020-00777-2
Fibrotic scarring after inflammation is well-characterized in peripheral tissues, but its role in the CNS is less clear. A new study shows that local proliferation of CNS fibroblasts drives fibrotic scar formation in response to circulating inflammatory cell infiltration in a model of multiple sclerosis, which may limit repair.
Inflammation drives fibrotic scars in the CNS
