October 31, 2020

Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations

Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in motor neurons of almost all amyotrophic lateral sclerosis (ALS) patients, and mutations in TDP-43 are also present in ALS. Loss and gain…

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