December 1, 2020

How aging affect microglial response to injury.

A research done by Conde et al, in Neurobiology of aging, 2006. is worth highlighting as it features the effect of age on the vigilant brain immune cells (Microglia) and its response to injuries.

They’ve highlighted

• Microglial response to injury across different rats ages and how it tends to be more porinflammatory as the rats age.

• They used DNA labeling with 3H-thymidine, TUNEL and lectin histochemistry after facial nerve axotomy in young (3months), middle-aged (15 months), and old (30 months) Fisher344-Brown Norway hybrid rats.

• Proliferation of microglia in old rats remained significantly higher than in young rats 4 days after injury, suggesting that regulation of microglial proliferation changes with aging.

• Their final assumption was aging-related changes in morphology in conjunction with a less regulated proliferative response in the aged facial nucleus may be a reflection of microglial senescence.

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