May 18, 2021

Customizing Multifunctional Neural Interfaces through Thermal Drawing Process

<p>Fiber drawing enables scalable fabrication of multifunctional flexible fibers that integrate electrical, optical and microfluidic modalities to record and modulate neural activity. Constraints on thermomechanical properties of materials, however, have …

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Cortical network structure mediates response to stimulation: an optogenetic study in non-human primates

<p>Brain stimulation interventions are used for the treatment of neurological disorders such as Parkinson’s and depression. Despite some success, the effects of stimulation are poorly understood, as evidenced by unknown …

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The mirror neuron system compensates for amygdala dysfunction-associated social deficits in individuals with higher autistic traits

<p>The amygdala is a core node in the social brain which exhibits structural and functional abnormalities in Autism spectrum disorder and there is evidence that the mirror neuron system (MNS) …

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Mobile Footprinting: Linking Individual Distinctiveness in Mobility Patterns to Mood, Sleep, and Brain Functional Connectivity

<p>Mapping individual differences in behavior is fundamental to personalized neuroscience. Here, we establish that statistical patterns of smartphone-based mobility features represent unique footprints that allow individual identification. Critically, mobility footprints …

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Fiberoptic Probe For Hemodynamic Spectroscopy in Freely Moving Mice Shows Cerebrovascular Dysregulation In Alzheimers and Glioma Models

<p>Significance: Cerebral vascular reactivity is critical parameters of brain homeostasis in health and disease, but the investigational value of brain oxymetry is diminished by anesthesia and mechanical fixation of the …

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Basal Ganglia Responses to Electrical Stimulation of the Posterior Hypothalamic Nucleus

<p>Electrical or chemical stimulation of the posterior hypothalamic nucleus (PH) elicits highly adaptive locomotion, demonstrating both evidence of flexibility and variety in exhibited motor behaviours. However, the neural substrates of …

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Astrocyte Ca2+ Signaling is Facilitated in an Scn1a+/- Mouse Model of Dravet Syndrome

<p>Dravet syndrome (DS) is an infantile-onset epileptic encephalopathy. More than 80% of DS patients have a heterozygous mutation in SCN1A, which encodes a subunit of the voltage-gated sodium channel, Nav1.1, …

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Deconstructing the Cortical Sources of Frequency Following Responses to Speech: A Cross-species Approach

<p>Time-varying pitch is a vital cue in the processing of speech signals. Neural processing of time-varying pitch cues in speech has been extensively assayed using scalp-recorded frequency-following responses (FFRs), which …

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Attentional modulation of intrinsic timescales in visual cortex and spatial networks

<p>Neural activity fluctuates endogenously on timescales varying across the neocortex. The variation in these intrinsic timescales relates to the functional specialization of cortical areas and their involvement in the temporal …

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Spatiotemporal context modulates encoding and retrieval of overlapping events

<p>Overlap between events can lead to interference due to a tradeoff between encoding the present event and retrieving the past event. Temporal context information — ‘when’ something occurred, a defining …

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