October 24, 2020

Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective

Nature Neuroscience, Published online: 17 August 2020; doi:10.1038/s41593-020-0690-y

Parkinson’s disease brain neurons exhibit a widespread epigenetic dysregulation of enhancers that is linked to an upregulation of TET2. Inactivation of TET2 protects against nigral dopaminergic neuronal loss and neuroinflammation.

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