October 30, 2020

Distinct place cell dynamics in CA1 and CA3 encode experience in new contexts

We compared trial-by-trial dynamics of place cells in CA1 and CA3 in new contexts across days. We found that CA1 place fields form early but shift backwards with experience and partially remap across days. In contrast, CA3 place fields develop gradually but remain stable with experience and across days. This suggests distinct plasticity mechanisms drive the formation and dynamics of place fields in CA1 and CA3 to encode distinct features of experience.

 bioRxiv Subject Collection: Neuroscience

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