October 24, 2020

Direct Readout of Neural Stem Cell Transgenesis with an Integration-Coupled Gene Expression Switch

Kumamoto et al. introduce iOn, a genetic switch that conditions exogenous transgene expression to integration in the host cell genome by DNA transposition. This system radically simplifies stable transgenesis with one or multiple plasmid vectors, opening new options to genetically manipulate cells in cultured systems and model organisms.


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