October 22, 2020

CRISPR Rube Goldberg machines for visualizing cell lineage

Nature Neuroscience, Published online: 07 August 2020; doi:10.1038/s41593-020-0694-7

A new technique developed by Garcia-Marques and colleagues uses CRISPR–Cas9 editing to activate an ordered sequence of fluorescent markers in stem cells and their progeny. These tools represent a new way to probe the spatial and temporal patterns of cell lineage progression.

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