January 17, 2021

Cortical depth-dependent human fMRI of resting-state networks using EPIK

Recent laminar-fMRI studies have provided substantial understanding of the evoked cortical responses in multiple sub-systems; in contrast, the laminar component of resting-state networks remains largely unknown. Here, we used EPIK, which offers unprecedented coverage at sub-millimetre resolution, to investigate cortical resting-state dynamics with depth specificity. After verifying laminar activation profiles in response to a task, we investigated whole-brain laminar dynamics. During rest, signal oscillations were stronger in the superficial layers of the cortical ribbon, and functional connectivity analysis indicated that most resting-state cortical connections occurring at rest involve supra-granular layers. Coherence assessed in a lateral motor network suggested a modified distribution of layer-specific responses during task performance compared to resting-state. Whole-brain evaluation of laminar-fMRI encompasses unprecedented computational challenges; nonetheless, it enables a new dimension of the human cerebral cortex to be investigated from a global view, which may be key in the characterization of neurological disorders from a novel perspective.

 bioRxiv Subject Collection: Neuroscience

 Read More

Leave a Reply

%d bloggers like this: