April 12, 2021

Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable

Using astrocyte RNA sequencing, Yu et al. demonstrate context-specific molecular responses of striatal astrocytes to multiple experimental perturbations. They identify reciprocal changes between Huntington’s disease (HD) and activation of the astrocyte Gi-GPCR pathway. Selective stimulation of the striatal astrocyte Gi-GPCR pathway corrects several HD-associated cellular and behavioral phenotypes.


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