October 31, 2020

Climbing fiber synapses rapidly and transiently inhibit neighboring Purkinje cells via ephaptic coupling

Nature Neuroscience, Published online: 07 September 2020; doi:10.1038/s41593-020-0701-z

Han et al. find that, in addition to powerfully exciting Purkinje cells, climbing fibers rapidly suppress firing in nearby Purkinje cells. Current from glutamate receptor activation generates large extracellular signals that inhibit neighboring cells.

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