January 28, 2021

Chronic deep brain stimulation of the human nucleus accumbens region disrupts the stability of inter-temporal preferences.

When choosing between rewards that differ in temporal proximity (inter-temporal choice), human preferences are typically stable, constituting a clinically-relevant transdiagnostic trait. Here we show in patients undergoing deep brain stimulation (DBS) to the anterior limb of the internal capsule / nucleus accumbens for treatment-resistant obsessive-compulsive disorder, that chronic (but not acute) DBS disrupts inter-temporal preferences. Findings support a contribution of the human nucleus accumbens region to preference stability over time.

 bioRxiv Subject Collection: Neuroscience

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