May 9, 2021

Multitask learning on comorbid disorders improves gene risk prediction for Autism Spectrum Disorder and Intellectual Disability

Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) are comorbid neurodevelopmental disorders with complex genetic architectures. Despite large-scale sequencing studies only a fraction of the risk genes were identified for …

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Genetic polymorphisms do not predict inter-individual variability to direct current stimulation of the primary motor cortex

High variability between individuals (i.e. inter-individual variability) in response to transcranial direct current stimulation (tDCS) has become a commonly reported issue in the tDCS literature in recent years. Inherent genetic …

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Temporal hierarchy converges with spatial hierarchy: Intrinsic neural timescales follow core-periphery organization

The human cortex exhibits a temporal hierarchy during task states as evidenced by intrinsic neural timescale. How the task-based intrinsic neural timescale is shaped by resting state’s spatial topography especially …

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CK2 inhibits TIMELESS nuclear export and modulates CLOCK transcriptional activity to regulate circadian rhythms

Circadian clocks orchestrate daily rhythms in organismal physiology and behavior to promote optimal performance and fitness. In Drosophila, key pacemaker proteins PERIOD (PER) and TIMELESS (TIM) are progressively phosphorylated to …

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Auditory aversion in absolute pitch possessors

Absolute pitch (AP) refers to the ability of identifying the pitch of a given tone without reliance on any reference pitch. The downside of possessing AP may be the experience …

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Pandora: 4-D white matter bundle population-based atlasesderived from diffusion MRI fiber tractography

Brain atlases have proven to be valuable neuroscience tools for localizing regions of interest and performing statistical inferences on populations. Although many human brain atlases exist, most do not contain …

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APP binds to the EGFR ligands HB-EGF and EGF, acting synergistically with EGF to promote ERK signaling and neuritogenesis

The amyloid precursor protein (APP) is a transmembrane glycoprotein central to Alzheimer’s disease (AD) with functions in brain development and plasticity, including in neurogenesis and neurite outgrowth. Epidermal growth factor …

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Functional Suppression of Premotor Activity in a Transient Model of Motor Cortex Injury

Cortical injuries (e.g. strokes or traumatic brain injuries) can create a host of secondary events that further impair the brain’s sensory, motor, or cognitive capabilities. Here, we attempted to isolate …

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Spatiotemporal Dynamics of Sound Representations Reveal a Hierarchical Progression of Category Selectivity

As the human brain transforms incoming sounds, it remains unclear whether semantic meaning is assigned via distributed, domain-general architectures or specialized hierarchical streams. Here we show that the spatiotemporal progression …

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Anatomical Plasticity of the Distal Forelimb Projection of the Ventral Premotor Cortex Four weeks After Primary Motor Cortex Injury

Brain injury affecting the isocortical frontal cortex is a common pathological occurrence. Many patients report severe deficits to functions of daily living. However, there is a variable degree of motor …

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