February 25, 2021

Super-resolution segmentation network for reconstruction of packed neurites

Neuron reconstruction can provide the quantitative data required for measuring the neuronal morphology and is crucial in the field of brain research. However, the difficulty in reconstructing packed neuritis, wherein …

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How does it feel to be on psilocybin?

Psilocybin is the active component of magic mushrooms and is well known for its psychoactive properties. Different questionnaires have been developed to systematically quantify altered states of consciousness induced by …

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Cholinergic upregulation by optogenetic stimulation of nucleus basalis in mice

A network of acetylcholinergic (ACh) cell groups in the basal forebrain innerve the forebrain and are proposed to contribute to a variety of functions including attention, and cortical plasticity. This …

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Neuroprotective effects of motherhood on brain function in late-life: a resting state fMRI study.

The maternal brain undergoes structural and functional plasticity during pregnancy and the postpartum period. Little is known about functional plasticity outside caregiving-specific contexts, and whether changes persist across the lifespan. …

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NMDA receptors require multiple pre-opening gating steps for efficient synaptic activity

NMDA receptors (NMDAR) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission in the nervous system. A central feature of NMDAR physiology is the opening of …

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Entraining corticocortical plasticity changes oscillatory activity in action control and inhibition

Oscillatory activity may reflect interactions between brain areas[1]. Here we tested whether inducing corticocortical plasticity in a specific set of connections changes oscillatory activity and cortico-cortical interactions and, if this …

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Functional Analysis of Distinct Populations of Subthalamic Nucleus Neurons on Parkinson Disease and OCD-like Behaviors in Mice

The Subthalamic Nucleus (STN) is a component of the basal ganglia and plays a key role to control movement and limbic-associative functions. STN modulation with Deep Brain Stimulation (DBS) improves …

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Lipid suppressed and tissue-fraction corrected metabolic distributions in human central brain structures using 2D 1H Magnetic Resonance Spectroscopic Imaging at 7 tesla

Magnetic resonance spectroscopic imaging (MRSI) has the potential to add a layer of understanding of the neurobiological mechanisms underlying brain diseases, disease progression, and treatment efficacy. Limitations related to metabolite …

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Empathy for pain

The neural mechanisms underpinning empathy for pain are still a matter of debate. One of the major questions is whether empathy-related pain responses indicate domain-general vs. pain-specific affective responses. Using …

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Speech-in-noise intelligibility difficulties with age: the role of cochlear synaptopathy

Damage to auditory-nerve-fiber synapses (i.e. cochlear synaptopathy) degrades the neural coding of sound and is predicted to impair sound perception in noisy listening environments. However, establishing a causal relationship between …

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