February 26, 2021

Prolonged epigenetic and synaptic plasticity alterations following single exposure to a psychedelic in mice

Clinical evidence suggests a potential therapeutic effect of classic psychedelics for the treatment of depression. The most outstanding and distinct characteristic is the rapid and sustained antidepressant action with one …

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Modelling seeding and neuroanatomic spread of pathology in amyotrophic lateral sclerosis

The neurodegenerative disorder amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of upper and lower motor neurons, with pathological involvement of cerebral motor and, additionally, extra-motor areas, in …

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DYRK1A role in microtubule-based axonal transport regulates the retrograde dynamics of APP vesicles in human neurons

In Alzheimer s Disease (AD) the abnormal intracellular distribution of the amyloid precursor protein (APP) affects its processing and, consequently, the generation of A{beta}. Axonal transport plays key roles in …

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Outcomes of Progranulin Gene Therapy in the Retina are Dependent on Time of Delivery

Neuronal ceroid lipofuscinosis (NCL) is a family of neurodegenerative diseases caused by mutations to genes related to lysosomal function. One variant, CNL11, is caused by mutations to the gene encoding …

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Extracellular S100B alters spontaneous Ca2+ fluxes in dopaminergic neurons via L-type voltage gated calcium channels: Implications for Parkinson’s disease

Parkinson’s disease (PD) is associated with an abnormal increase in S100B within the midbrain and cerebrospinal fluid. In addition, overexpression of S100B in mice accelerates the loss of substantia nigra …

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Toroidal topology of population activity in grid cells

The medial entorhinal cortex (MEC) is part of a neural system for mapping a subject’s position within a physical environment. Grid cells, a key component of this system, fire in …

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More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing

Corticokinematic coherence (CKC) quantifies the phase coupling between limb kinematics and cortical neurophysiological signals reflecting proprioceptive feedback to the primary sensorimotor (SM1) cortex. We studied CKC to proprioceptive stimulation (i.e. …

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Power spectra reveal distinct BOLD resting-state time courses in white matter

Accurate characterization of the time courses of BOLD signal changes is crucial for the analysis and interpretation of functional MRI data. While several studies have shown that white matter (WM) …

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An Adeno-Associated Viral vector encoding Neurotrophin 3 injected into affected forelimb muscles modestly improves sensorimotor function after contusive mid-cervical spinal cord injury.

Traumatic spinal cord injury (SCI) in humans occurs most frequently in the cervical spine where it can cause substantial sensorimotor impairments to upper limb function. The altered input to spinal …

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A synaptic novelty signal in the dentate gyrus supports switching hippocampal attractor networks from generalization to discrimination

Episodic memory formation and recall are complementary processes that put conflicting requirements on neuronal computations in the hippocampus. How this challenge is resolved in hippocampal circuits is unclear. To address …

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