November 25, 2020

Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults

Publication date: September 2020

Source: Neurobiology of Aging, Volume 93


Novel biomarkers related to neuronal damage, neuroinflammation, and axonal damage cluster with tau biomarkers, but not with Aβ42.
Cognitively unimpaired older adults can be classified in subgroups based on biomarker profiles.
Biomarker profiling of older adults beyond amyloid and tau improved prediction of memory decline.
Some older adults are cognitively resilient to brain changes as indexed by various biomarkers.

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