November 29, 2020

Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

Nature Neuroscience, Published online: 08 June 2020; doi:10.1038/s41593-020-0650-6

Andreone, Przybyla et al. used induced pluripotent stem cell-derived human microglia to show that TREM2-dependent phagocytosis and lipid metabolism require the Alzheimer’s risk factor PLCγ2, which can also mediate TREM2-independent inflammatory signaling via Toll-like receptors.

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