October 27, 2020

All Talk, No Assembly: Voltage-Gated Calcium Channels Do Not Mediate Active Zone Formation

How synapses assemble remains unknown. In this issue of Neuron, Held et al. (2020) demonstrate that Cav2-type voltage-gated calcium channels do not mediate presynaptic assembly. Moreover, the channel-associated protein α2δ localizes independently, suggesting additional functions for this auxiliary protein.


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