February 27, 2021

A standardized behavioral event equally impacts the activity of cortical visual areas and layers

Multiple recent studies have shown that motor activity greatly impacts the activity of primary sensory areas like V1. Yet, the role of this motor related activity in sensory processing is still unclear. Here we further dissect how these behavior relevant signals are broadcast to different layers and areas of visual cortex. To do so, we leveraged a standardized motor behavior fidget event in behavioral videos of passively viewing mice. A large two photon Ca 2+ imaging database of neuronal responses uncovered four neural response types during fidgets that are surprisingly consistent in their proportion and response patterns across all visual areas and layers of the visual cortex. Indeed, the layer and area identity could not be decoded above chance level based only on neuronal recordings. The broad availability of standardized behavior signals could be a key component in how the cortex selects, learns and binds local sensory information with relevant motor outputs.

 bioRxiv Subject Collection: Neuroscience

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