November 24, 2020

A programmable sequence of reporters for lineage analysis

Nature Neuroscience, Published online: 27 July 2020; doi:10.1038/s41593-020-0676-9

Garcia-Marques et al. present CLADES, an innovative approach to study neuronal lineages based on CRISPR. Inspired by synthetic biology, CLADES relies on a system of genetic switches to activate and inactivate reporter genes in a predetermined order.

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