November 28, 2020

A Novel Neurovascular Liaison Governing the Blood-Brain Barrier

How circulating signals enter the median eminence to trigger homeostatic hypothalamic responses is not well understood. Jiang et al. describe a neural mechanism that increases endothelial fenestrations and enhances the hypothalamic response to the circulating hormone leptin, suggesting a novel way to regulate brain entry through vascular wall remodeling.

 Neuron

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