November 25, 2020

A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y

NLGN4X and NLGN4Y are thought to have similar functions due to their ∼97% shared amino acid identity. Nguyen et al. demonstrate NLGN4Y has a deficit in trafficking due to one amino acid difference. The trafficking deficit phenotype is also found in a cluster of autism-associated variants in NLGN4X near the critical amino acid.
Neuron

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