May 9, 2021

T-type Ca2+ and persistent Na+ currents synergistically elevate ventral, not dorsal, entorhinal cortical stellate cell excitability

<p>The medial entorhinal cortex (mEC) plays a salient role in physiological processes such as spatial cognition and spatial coding. mEC layer II stellate neurons, in particular, influence these processes. Interestingly, …

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Modelling the depth-dependent VASO and BOLD responses in human primary visual cortex

<p>Functional magnetic resonance imaging (fMRI) using blood-oxygenation-level-dependent (BOLD) contrast is a common method for studying human brain function non-invasively. Gradient-echo (GRE) BOLD is highly sensitive to the blood oxygenation change …

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TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy

<p>The neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TAR DNA-binding protein-43 (TDP-43) inclusions (FTLD-TDP) share the neuropathological hallmark of aggregates of TDP-43. However, factors governing the …

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Feeling younger buffers older adults from stress, protects against health decline

<p>People who feel younger have a greater sense of well-being, better cognitive functioning, less inflammation, lower risk of hospitalization and even live longer than their older-feeling peers. A study suggests …

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Why do some neurons degenerate and die in Alzheimer’s disease, but not others?

<p>Researchers have uncovered molecular clues that help explain what makes some neurons more susceptible than others in Alzheimer’s disease. The scientists present evidence that neurons with high levels of the …

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Why do some neurons degenerate and die in Alzheimer’s disease, but not others?

<p>Researchers have uncovered molecular clues that help explain what makes some neurons more susceptible than others in Alzheimer’s disease. The scientists present evidence that neurons with high levels of the …

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Agrin/Lrp4 signal constrains MuSK activity during neuromuscular synapse development in appendicular muscle

<p>The receptor tyrosine kinase MuSK, its co-receptor Lrp4 and the Agrin ligand constitute a signaling pathway critical in axial muscle for neuromuscular synapse development, yet whether this pathway functions similarly …

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The non-genomic vitamin D pathway links ╬▓-amyloid to autophagic apoptosis in Alzheimer’s disease

<p>Vitamin D is an important hormonal molecule, which exerts genomic and non-genomic actions in maintaining brain development and adult brain health. Many epidemiological studies have associated vitamin D deficiency with …

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Fixel-Based Analysis and Free Water Corrected DTI Evaluation of HIV Associated Neurocognitive Disorders

<p>Background: White matter (WM) damage is a consistent finding in HIV infected (HIV+) individuals. Previous studies have evaluated WM fiber tract specific brain regions in HIV-associated neurocognitive disorders (HAND) using …

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Corticothalamic Projections Deliver Enhanced-Responses to Medial Geniculate Body as a Function of the Temporal Reliability of the Stimulus

<p>Aging and challenging signal-in-noise conditions are known to engage use of cortical resources to help maintain speech understanding. Extensive corticothalamic projections are thought to provide attentional, mnemonic and cognitive-related inputs …

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